Who were the winners and losers? After an 11-club tour of Europe, including stops at Manchester United and Leicester City (where he won the Premier League title!) he's back where it all began and tonight he used all those years of experience to shut Spurs out.
A heroic display from De Laet! Mourinho's obviously got previous for subbing people off at half-time, but usually in desperate situations, not simply being 1-0 down.
Owen Hargreaves added: 'He (Alli)'s lacking in confidence and he's making mistakes. This was nearly vindictive from the Portuguese coach, but whatever his motives, those four players must be feeling bad. But it just didn't happen for him.
"We believe that with the squad that we have, even with rotation, the team will keep the level and the quality of play". Maybe a consolation, or perhaps a tasty equaliser before an inevitable defeat, but a victor?
Ben Davies was at fault as he was caught in possession by Dieumerci Mbokani and he raced away, teeing up Refaelov to fire home in clinical fashion.
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"In the first half the game was very easy to play, lots of space".
It's probably the latter, right?
Gareth Bale was next to make way on the hour-mark but the introduction of Pierre-Emile Hojbjerg, Erik Lamela, Lucas Moura, Son Heung-min and Harry Kane made little difference. A big player like him, travelled to Burnley on Monday, stayed on the bench for 90 minutes, didn't play one minute.
Davinson Sánchez is usually great but tonight he was an absolute trainwreck.
Royal Antwerp's Lior Refaelov celebrates with team-mates after their opening goal.
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'He was just stopping the ball deal instead of keeping it moving.
Spurs beat LASK 3-0 last week and were looking for a repeat performance, but it proved to be a hard night for Jose Mourinho's men.
On the eve of the game, Mourinho had said he was "deeply hurt" every time he could not start one of his players but afterwards he suggested he would feel less inclined to give opportunities to his fringe players.
Asked if any players put forward their case to start more regularly, Mourinho said: "Look, you know what our best team is".
"There's only one person to blame, and it is me. I'M HELPING!" multi-man half-time substitutions, it had basically no effect.
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"Bad performances deserve bad results", Mourinho wrote. His options are there and he's trying his best but it's not happening for him.