USA man gets COVID-19 twice, raising questions about immunity

Credit University of Arizona

Credit University of Arizona

The man reported feeling well from April 27 until May 28, and two "nucleic acid amplification tests" conducted after his symptoms had resolved came back negative for the novel coronavirus, according to the case study. Researchers developed an antibody blood test that is accurate more than 99 percent of the time, and tested almost six thousand people in Pima County.

A Nevada man has been reinfected with the coronavirus, the first documented case in the United States.

A resident of Washoe County, the man received a positive COVID-19 result at a community testing event in April, where he reported symptoms such as sore throat, cough, headache and diarrhea. "Hearing loss and tinnitus are symptoms that have been seen in patients with both COVID-19 and influenza virus, but have not been highlighted", they added.

In a linked comment to the study, Akiko Iwasaka, a professor of Immunobiology and Molecular, Cellular and Developmental Biology at Yale University, said the findings could impact public health measures.

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June 5 - He tests positive again.

The second study involved 95 people who were critically ill with Covid-19 in Vancouver, Canada. "The second infection was symptomatically more severe than the first", said the journal.

Following a series of hearing tests, the doctors treating the man determined that inflammation was not the cause of his hearing loss. "We don't learn much about horses by chasing unicorns, and the same is true for studying immune responses", she tweeted. They hypothesized that the parent's infection could have been "a possible source for secondary exposure and reinfection of [the] patient".

"Most people agree, it's starting with health care workers, and front-line workers, but even there, you need to define which of them are at highest risk, and then the elderly, and so on", Swaminathan said.

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As scientists are trying to make sense of SARS-CoV-2, the virus that causes Covid-19, a new study has found that not only is reinfection possible, but that individuals may actually experience more severe symptoms the second time they are infected.

Researchers of a separate study published in Nature, said that ADE is a concern for the development of vaccines and antibody therapies as there is the potential of amplifying an infection or triggering harmful immunopathology. While the body's immune system can be hampered by proteins deployed by the novel coronavirus, the immune response produced by a vaccine is not as vulnerable to proteins, Iwasaki explained. "Especially since we don't know how common reinfection is", Rasmussen says. Since blood group distributions vary among ethnic subgroups, the researchers also controlled for ethnicity and maintained that fewer people with blood type O tested positive for the virus.

"The latest time-points we tracked in infected individuals were past seven months, so that is the longest period of time we can confirm immunity lasts", Dr. Bhattacharya said.

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