Panel Recommends Oxford COVID Vaccine Partner For Phase 2,3 Human Trial

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Panel Recommends Oxford COVID Vaccine Partner For Phase 2,3 Human Trial

Operation Warp Speed is the name of the government's all-out blitz to develop a vaccine by the end of this year. Barouch's group, in collaboration with Johnson & Johnson, developed a series of vaccine candidates created to express different variants of the SARS-CoV-2 spike protein, which is the major target for neutralizing antibodies. Dan H. Barouch, an immunologist, has worked for this vaccine since January after China exposed the viral genome.

The vaccine used by J&J includes a common cold virus adenovirus type 26 or Ad26 for taking coronavirus proteins in the body cells, causing an enhancement in immune defense by the body against the virus.

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Researchers tested one of seven different single-dose vaccine candidates from the J&J Janssen unit in 32 rhesus monkeys. The high levels of infection were developed in the nasal swabs and lungs of all those animals who have taken placebo shots. And the six that got the optimal vaccine did not suffer from the virus, and only one animal showed the lower levels of virus in nasal swabs. All vaccinated animals developed neutralizing antibodies following immunization. The Lancet Medical Journal also reported in a report that the results of the vaccine that Oxford University is producing are encouraging and it seems to be completely safe.

Initial results of the first two-phase trials of the vaccine conducted in five trial sites in the United Kingdom showed it has an acceptable safety profile and homologous boosting increased antibody responses, the source said. This is practically logistic in the global need for the vaccine.

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Investigators at Beth Israel Deaconess Medical Center (BIDMC) and other institutions have initiated a first-in-human Phase 1/2 clinical trial of the Ad26.COV2.S vaccine in healthy volunteers. Scientists are planning to do human trials with this vaccine shortly to deliver the safety and efficacy of it.

Following the study, a Phase 1/2a first-in-human clinical trial of the vaccine candidate has now commenced in healthy volunteers in the United States and Belgium. Kathryn E. Stephenson, MD, MPH, is the principal investigator for the trial at BIDMC, which is funded by Janssen Vaccines & Prevention, B.V., a pharmaceutical research arm of Johnson & Johnson.

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