The incident happened at around 6am local time.
Tempe Police noted on Twitter that several roads are now restricted following the incident, and warned residents to "please avoid the area".
USA announces withdrawal of almost 12,000 troops from Germany
Numerous remaining forces will be based in the USA but will rotate into Europe for temporary deployments without their families. Esper said he would like some moves will start within a matter of weeks, but there are still consultations ahead.
Tempe police tweeted: '@TempePolice and Tempe Fire are on scene of a train derailment and large fire over Tempe Town Lake.
Johnny Grove, who filmed this, posted online: "One of Tempe's oldest train tracks over Tempe Town Lake on fire from a train". It' looks like a scene from hell, truly.
Service Alert: Buses are now transporting passengers around the fire scene in Tempe.
Hong Kong economy reels as tough virus restrictions implemented
Hong Kong reported 106 new COVID-19 cases on Tuesday, including 98 that were locally transmitted. Face masks must also be worn in all public places, the BBC reported.
Tempe police and fire crews have rushed to the scene where thick smoke has filled the air. The crash is being described as second-alarm hazardous until first responders can determine whether or not any hazardous materials were being transported on board. Valley Metro light rail service in the area has been interrupted. The fire was reported about 6 a.m. PST.
A derailed tanker was also labeled with a hazardous materials sign.
Plumes of smoke could be seen rising into the morning sky beneath a trail of flames on video and images from the site of the derailment, where part of the bridge collapsed.
US to bring 6400 troops home from Germany, move 5600 more
He added that Germany is one of the wealthiest countries in Europe "and should pay more for its defense". The timeline suggests that the plan could be reversed should Trump lose the election in November .
The 2.5-mile man-made lake near Arizona State University is a popular recreation spot for jogging, cycling and boating.