Trial starts with Imperial College London coronavirus vaccine

Human trial of COVID-19 vaccine begins in UK

Trial starts with Imperial College London coronavirus vaccine

Oxford University, in conjunction with South Africa's University of the Witwatersrand, announced Wednesday thousands of volunteers between the ages of 18 and 65 who received the vaccination will be monitored for 12 months to see how well the vaccine guards against COVID-19.

Groups including the vaccine alliance GAVI are also working to buy doses for poor countries and AstraZeneca has agreed to license its vaccine to India's Serum Institute for the production of 1 billion doses.

"Our country may also produce the vaccine following the result of the trial", he added.

The team will test the Ox1Cov-19 Vaccine, often known as the Oxford Vaccine, as part of the VIDA-Trial that aims to find a vaccine for SARS-CoV-2.

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The volunteer was given a low dosage of the vaccine, with a booster follow-up in four weeks' time.

Stephen Griffin, an associate professor at Leeds University who was not directly involved in this work, said it was "an encouraging advance" and showed that "a so-called "prime-boost" strategy gives rise to far better responses" than a single dose.

It has started testing a few weeks later than another vaccine candidate developed by the University of Oxford and AstraZeneca - ChAdOx1 nCoV-19, now renamed AZD1222 - which uses a viral vector to introduce genetic material from the virus and produce an immune response.

Around 300 healthy participants are expected take part in this trial.

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In a trial on rhesus macaques, a single dose of the vaccine was found to be effective in preventing pneumonia but unable to prevent infection when the vaccinated animals were exposed to the virus.

"We are now poised to test the vaccine in the dose evaluation phase before moving forward to evaluating it in larger numbers".

Speaking on the vaccine, Katrina Pollock of the department of infectious disease and chief investigator of the study, said: "We have reached a significant milestone in this ground-breaking study with the first dose of a self-amplifying RNA vaccine delivered safely".

Imperial has also formed a new social enterprise called VacEquity Global Health (VGH) to develop and distribute its vaccine across the United Kingdom and worldwide. "This is a landmark moment for South Africa and Africa at this stage of the COVID-19 pandemic".

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