The Medicines and Healthcare products Regulatory Agency and the Early Access to Medicines Scheme are supporting the administration of remdesivir, which inhibits RNA-dependent RNA polymerase, conflicting with RNA replication, in selected COVID-19 patients.
The Searle Company Limited has successfully entered into an exclusive licensing and marketing agreement with Beximco Pharmaceuticals, Bangladesh for marketing of Covid-19 drug Remdesivir, informed the company in a statement to the Pakistan Stock Exchange on Friday.
According to a BBC report, the United Kingdom has authorized the use of the anti-viral drug Remdesivir in treating patients with the novel coronavirus as experts have discovered that the drug could shorten the recovery time of infected individuals.
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The preliminary findings, based on an analysis of 1059 participants, noted that patients who received remdesivir had a shorter time to recovery than those who received placebo.
Britain will provide the anti-viral drug remdesivir to certain COVID-19 patients that it is most likely to benefit as part of a collaboration with manufacturer Gilead Sciences, the health ministry said on Tuesday. The COVID-19 drug is still undergoing clinical trials in medical facilities across the globe, including in the UK.
The 450-patient phase 3 trial is pairing Gilead's polymerase inhibitor remdesivir - created to inhibit replication of the virus - with Roche's IL-6 inhibitor Actemra/RoActemra (tocilizumab) which acts as an anti-inflammatory drug. He said that while this approach was the most ethical, it also meant drug would not be a "magic bullet". He also clarified that the patients with the most severe medical conditions will receive the anti-viral drug first.
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The researchers said the mortality rate of 7 per cent at 14 days in the remdesivir arm indicated the need to evaluate antivirals with other therapeutic agents to continue to improve clinical outcomes for patients with Covid-19.
It will also be available for clinical trials, and several trials testing remdesivir and its possible effects on patients with COVID-19 have already been approved by the MHRA and are ongoing in the UK. The overreaction of the immune system for the virus can be prevented by immune-suppressing drugs. He said that they have beaten TB and HIV through a combination of antibiotics and antiretrovirals, expecting that the novel coronavirus can only be cured with the same method.
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Still, there have been optimistic signs of relief for the U.S. , with numerous worse-hit areas seeing key measures declining. The overall death toll is now 98,875, and the number of cases of infection stands at more than 1.68 million, it said.