WHO Director General Tedros Adhanom Ghebreyesus on Monday said the agency's Executive Group implemented a temporary pause of the hydroxychloroquine arm within the Solidarity Trial while safety data is reviewed by the Data Safety Monitoring Board. The earliest study that suggested it might yield benefits was problematic, as it was small and excluded patients in the study who became critically ill or died. Two specific outcomes were studied: overall mortality and occurrence of a cardiovascular event known as ventricular arrhythmia. Instead of becoming a cure, it was associated with an increased risk of death and heart complications.
Despite this conflict between public advocacy and clinical concern, countries have opted to stockpile the drugs in question over the past few months.
Whether or not the large volume of clinical trials now underway investigating this very treatment should even continue is another question entirely.
Mean patient age was 53.8 years, with 46.3% of observed patients being women.
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DNC leader Seema Nanda has also suggested postponing the convention in hope that this pandemic takes a different turn. National political conventions to nominate presidential candidates are a quadrennial tradition in the U.S.
Having sung the praises of hydroxychloroquine during his coronavirus briefings in March and April, Mr Trump stunned reporters on May 18 when he announced that he was taking it, even though he had not tested positive for COVID-19.
The study examined a total of 96,032 Covid-19 patients, 14,888 of whom received either hydroxychloroquine or chloroquine - with or without an antibiotic.
Four different treatment variations were included in the study: chloroquine alone, hydroxychloroquine alone, chloroquine with a macrolide or hydroxychloroquine with a macrolide.
Hydroxychloroquine clinical trials suspended by the WHO. Over 400 hospitals in 35 countries had been roped in to actively recruit patients and almost 3500 patients had already been enrolled from 17 countries. However, recruitment is being pursued in twice that many countries (35), including 400 hospitals. This is an effort overseen by the World Health Organization to find new treatments for COVID-19. "They are now reviewing this new evidence and implications for Ascot".
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Other trials into hydroxychloroquine were also halted, including the World Health Organisation's "solidarity" trial.
What is the Solidarity Trial? . Although India has not formally responded to the World Health Organization decision, but has made it clear that HCQ is completely safe and will continue its trial.
The review will consider the data collected to date, particularly random data, in order to adequately assess that drug's potential benefits and harms.
A statement from the ANSM (the national agency responsible for the safety of drugs and medical products) on Tuesday said that people now enrolled in clinical trials would be allowed to complete their treatment protocol, but new patients would not be enrolled.
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The husband and wife were joined by their daughters Leonor, 14, and Sofia, 13, at Zarzuela Palace in Madrid. Eight regions reported no coronavirus-related deaths in the last 24 hours.