Moderna's coronavirus vaccine shows initial immune response

A Moderna scientist works in the company's lab

A Moderna scientist works in the company's

Questions such as these may have even reversed Monday's stock market gains.

But was there good reason for so much enthusiasm? A gradual slide in the shares that began when trading opened gained momentum after a report from the health publication Stat highlighted the early nature of the vaccine data, helping to drag down the broader market. "Further, he has directed the divestiture of his equity holdings in Moderna and that sale should be effective tomorrow morning". But that data could be important. Here are a few reasons why.

Moderna, of Cambridge, Mass., codesigned its vaccine with the National Institute of Allergy and Infectious Diseases in January and rushed to manufacture doses for testing. It's also problematic that these results were released by Moderna itself, rather than in a peer-reviewed study or a preprint.

NIAID doesn't hide its light under a bushel. Samples for the other participants aren't yet available, according to the statement.

Critically, eight of them had produced "neutralising" antibodies - the ones that confer the greatest protection. This type of vaccine is meant to give a patient's cells a metaphorical building manual to create the "spike" on the coronavirus, which would manufacture an antibody response similar to what happens when one is naturally infected with the virus.

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Talc mines, however, can also yield asbestos, a mineral once used in products such as building insulation. If swallowed, these fibers can reach the abdominal lining, where they can cause mesothelioma.

Nevertheless, Stat said that was "still a reason for caution".

Now, phase one of Moderna's human safety tests included 45 participants between the ages of 18 and 55. The levels of antibodies in the mice, which was sufficient to block the virus, was also the same as in the humans dosed with the vaccine. Three study subjects developed "flu-like" conditions following a second shot of the large dose.

It would be cause for concern if an inside connection produces an early FDA approval of Moderna's vaccine despite a lack of firm evidence that it's safe and effective.

All eight of those participants (four receiving 25 µg and four receiving 100 µg) had neutralizing antibodies at or above levels seen in those who recovered from COVID-19.

But the levels of neutralizing antibodies were "at or above" convalescent serum.

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"I don't think that's sustainable", Eric Maskin, 2007 Nobel Laureate in economics, told CGTN in a video interview at the 2020 Tsinghua PBCSF Finance Forum held online in Beijing over the weekend, predicting a further fall after the rally, adding "financial markets have not yet bottomed out".

The biotech firm announced plans to sell 17.6 million shares priced at $76 apiece in a public offering that's expected to close around Thursday. What we've mostly established this morning is that Moderna works fast, and people really, really, really want a vaccine.

Manning said that, overall, vaccines are developed particularly for pathogens and agents that cause the highest frequencies and worst diseases that we've seen throughout history. That's not enough to generate confidence within the scientific community. The company has more than 20 drugs in the pipeline, including potential treatments for rare diseases and cancer, and nine possible vaccines against various viruses. "They have not published any of that".

That said, the fact that preliminary evidence show this vaccine looks to be safe and can stimulate the immune system is a good sign. "We don't know if those antibodies are durable".

Moderna Announces Positive Interim Phase 1 Data for its mRNA Vaccine (mRNA-1273) Against Novel Coronavirus [news release].

Health officials provide daily COVID-19 update at 3 p.m.
Bonnie Henry said that since Saturday, there have been 16 more confirmed cases of COVID-19 and two more deaths recorded in BC. Currently, 45 people are in hospital for treatment of COVID-19, including 12 patients that require critical care.

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