And her aunt, Emily Mistry, stated that Chloe didn't have any preexisting health problems.
The youngest person in the United Kingdom to have died after contracting the coronavirus was an 18-year-old on March 23.
Ms Middleton's family urged the public to heed safety advice and take "this seriously".
The family described the "unimaginable pain" they are going through after "fit and healthy" Chloe tragically passed away on Wednesday.
Kevin Hart and wife expecting their second child
After that, he was also involved in a fatal vehicle crash accident in California, but luckily, he was able to recover from that. In a photo where she revealed the big bump, she said they are counting their blessings and couldn't more grateful.
Chloe's mother, Dianne Middleton posted on Facebook how the deadly pathogen is not "just a virus" as it took her daughter's life.
Chloe's aunt wrote: "My attractive, kind hearted 21 year old niece Chloe has passed away from Covid-19".
"The reality of this virus is only just unfolding before our very eyes".
"The prime minister has been clear on what we need to do: stay at home to protect our NHS and save lives", said Home Secretary (interior minister) Priti Patel.
Dow Jones sees record jump on Tuesday amid roller coaster month
The S&P 500's 9.4 per cent surge Tuesday was a better performance than the index has turned in for 10 of the last 20 full years. In other trading, USA crude oil gained 38 cents to $24.39 per barrel in electronic trading on the New York Mercantile Exchange.
The family, from High Wycombe, Buckinghamshire in the United Kingdom called on people to stay indoors to halt the spread of the virus.
"Do your bit. Protect yourselves and protect others". This virus could put you in hospital for weeks, or even kill you.
According to government figures, most patients who have died with coronavirus had pre-existing medical conditions.
Ms Middleton's sister, Amy Louise, added that it was "about time people took this seriously, before too many people end up in this devastating position".
Bindi Irwin marries Chandler Powell, lifelong love, at Australia Zoo
As of today, there were new restrictions put into play in Australia that limit weddings to a specific set of guidelines. At the beginning of March, Bindi posted an image of herself, Chandler and Robert holding her bridal bouquet flowers.
The country is three days into a three-week lockdown ordered by Prime Minister Boris Johnson in an effort to stem the surge in cases. According to the tally by global news agency, the pandemic has now spread to 198 countries and has infected at least 471,464 people.