The Russian fourth seed was pressed hard in a competitive first set before grinding down the 22-year-old 7-5, 6-1, 6-3 with the roof closed on Margaret Court Arena.
Dominic Thiem was dragged into a five-set absorbing fight by former ditch digger Alex Bolt before he emerged victorious to reach the third round of the Australian Open.
Austrian Thiem had a 5-3 lead in the second set but lost five games in a row, and it was Bolt who came out on top in a tight third-set tie-break.
Fourth seed Daniil Medvedev was a comfortable 7-5 6-1 6-3 victor against Pedro Martinez despite a bloody nose late in the second set. "Now into the third round, I'm very happy about that".
Medvedev will meet in the next round with the other Spaniard Jaume Munnar or Australian Alexei Bouberin in order to reserve his card to the final price, which he bid farewell to a year ago after the loss against Serbian Novak Djokovic, who continued his path until winning the title.
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Malgré un grand ter-Stegen, qui a réussi à stopper un penalty, les Barcelonais se sont montré peu dangereux. Le FC Barcelone s'est incliné 2-0 à Valence , samedi, lors de la 21e journée du championnat d'Espagne.
The US Open finalist called for a medical timeout while leading 5-0 in the second set and needed treatment to stop the bleeding. I think the body language wasn't the best, because of course it was in my head that I was 2-0, 6-2, 6-4, I should get up. "I knew that probably he can not really hold that level, so I just tried to stay in the match and it paid off". It gets more hot, more humid inside.
The pair stayed on serve until the Russian's pressure paid dividends in the first set, working break points in game four and getting the edge when Martinez, ranked 168, sent a backhand into the net.
Rising Australian star Alexei Popyrin charged into the third round of his home slam for the second straight year with a straight-sets win over Spaniard Jaume Munar.
Wawrinka, the 2014 Australian Open champion, defeated Andreas Seppi 4-6, 7-5, 6-3, 3-6, 6-4.
Thiem had to deal with a partisan crowd at Melbourne Arena but said he enjoyed the occasion.
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Germany seventh seed Alexander Zverev, who has yet to go beyond the fourth round in Australia, beat Belarusian Egor Gerasimov 7-6 (7-5) 6-4 7-5.
"It was a tough match", Thiem said.
Going by their past encounter, it won't be easy for the fourth seed, but given his form and experience, expect Medvedev to reach the fourth round with a four-set win. "There's a big difference if you play three hours 20 (minutes) in these conditions or if you play four-and-a-half when it's 40 degrees outside".
The rain stopped late morning and the weather is mostly cloudy with gusting winds. Still, organizers were again forced to postpone matches because of the weather, rescheduling seven women's and six men's first-round doubles matches to Friday.
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Australia is a popular destination for Chinese, with about 1.4 million short-term arrivals from China in 2019, Reuters reported. The disease is being listed as having "pandemic potential", which allows for enhanced border protection measures.