The Red Devils will be looking to bounce back and revive their top four ambitions following a 2-0 defeat against Liverpool on Sunday.
United trail six points behind fourth placed Chelsea but, given how they have struggled so often this season, the only surprise is that the gap isn't bigger. They've only had 10-12 games some of them.
The owners and executive vice-chairman Ed Woodward were subjected to many other chants on a miserable night for United, whose injury-hit side flailed after a promising start as the need for January reinforcements was laid bare.
If the Solskjaer's side get the basics wrong on the day, they could be in for a hard game.
His record since being promoted from caretaker boss to manager in March of a year ago consists of 19 wins, 11 draws and 15 defeats in all competitions.
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He lets her go because she's a good girl? You just need to do it like you did last time and not think about it and just do it babe.
Less than a month after his record-breaking caretaker stint led to his full-time appointment, the 1999 treble hero oversaw an alarming defeat to Marco Silva's Toffees.
"For us, we've just got to stick to our values, stick to our beliefs, knowing it's no use feeling sorry for yourself", Solskjaer told a news conference. But that's where we're at at the moment in terms of players. The players hear the fans. That's where we're at'.
August's home loss to Crystal Palace and the following month's meek display in defeat at West Ham were bad, but the 1-0 loss at St James' Park before the October worldwide break set off alarm bells.
'I'm sitting here embarrassed.
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"You can't defend this". Fans were walking out after 85 minutes. Fundamental changes need to be made to the way the club is run.
Do you think Solskjaer is the right man for the United job?
'Nothing there suggests this is laying the foundation of future. "I don't see it". "Of course, it's great having Eric [Bailly], Diogo [Dalot] and Luke [Shaw] back in so we have got more choices". Money has been spent willy-nilly in the past seven years, what's to show?'
United fans have been calling for the sack of manager Ole Gunnar Solskjaer considering the club unimpressive performances this season in all competitions. "We know that wasn't good enough today". We have started a clear-out and now I am going to be answering these questions until it [transfer window] closes. The players are disappointed but they gave everything once again - the effort is there.
Realistically, given they are 3-1 down following the home leg of their EFL Cup semi-final with Manchester City, the FA Cup and Europa League are United's only remaining chances of silverware this season.
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