Police added an 11-year-old boy was also shot and is undergoing surgery.
Five people are dead following a shooting in Southern California.
"There was some kind of argument or disagreement and he used the handgun and shot his family before turning the gun upon himself". Police initially identified the eldest child as the lone survivor, but later said it was too early to tell.
One of the victims, the 29-year-old mother, got a restraining order Friday, Dobbs said.
When police got to the home in the Paradise Hills neighborhood, they broke through a front window and went inside after they saw an injured child laying on the ground.
San Diego's homicide unit's Lieutenant Matt Dobbs said it was unclear whether the order had been served, but the father was aware of the order.
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Three other boys aged between five and 11 were transported to hospital for treatment where two other boys died.
Police said during a press conference Saturday that officers had responded to the Flintridge Drive address earlier in November, where they found the estranged couple arguing over a set of tools.
The names of the victims have not been released.
According to the San Diego Union-Tribune newspaper, the incident occurred on Saturday in Paradise Hill, a city located 35 km north of US-Mexico border, reports Xinhua news agency.
Dobbs said the crime scene was so gruesome it traumatized even the arriving officers, who carried the children out of the house in a desperate effort to save them.
The woman and four children lived in a granny flat adjacent to a house occupied by members of their extended family. At that time, police gave the wife with information as to how to retain a restraining order against her husband.
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A gun was found in the house.
"A senseless tragedy", San Diego Police Chief David Nisleit said.
Another neighbor, Gabriel Durazo, said he often saw the children from the granny flat riding their bicycles or playing with a dog.
Counseling is being provided to the first responders who arrived at the scene, Nisleit said.
The mom, who had not been named by authorities as of Saturday afternoon, lived with her kids in an apartment on the property, while their relatives lived in the main residence, neighbors told ABC 10.
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