A lot of folk suffered minor injuries after the incident which came about on Wednesday evening for the length of a efficiency of Demise Of A Salesman in London.
"Five members of the audience sustained minor injuries and were taken to local hospitals". The theatre was later evacuated.
The production, which premiered at the Young Vic earlier this year, explores the Arthur Miller drama through the lens of an African-American family.
The production features Hollywood actor Wendell Pierce and one witness, Tracy De Groose, said the star came out to check everyone was okay.
In 2013, about 80 people were injured, seven seriously, after part of the Apollo theatre's ceiling collapsed on top of them.
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Ceiling collapsed at Piccadilly Theatre before #DeathOfASalesman, but @WendellPierce is undeterred!
Police added that road closures have been put in place and advised motorists to use alternative routes. A few screams. Everyone evacuated.
London Fire Brigade said 1,100 people had been evacuated after a section of plaster fell from the ceiling.
It is not the first time a ceiling has collapsed in one of London's theatres. "We apologize and we're glad that no-one's hurt".
Mr George said: "About 10 minutes into the performance you could hear this slight dripping sound in the [Grand] circle and people were looking around, wondering what was happening, but the play carried on".
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He said water had been dripping, "which turned progressively into a stream".
"Then, as we stood up, this huge chunk of ceiling, about three to four metres across, crashed down".
Chief executive Jon Morgan said in a statement: "We do not know yet what caused this and it is important not to jump to conclusions until more details are known".
"On twitter, Laura Kate Jones described the incident as 'terrifying", saying people were "running and screaming to get out".
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