Roger Federer predicted earlier this week that it would be hard for the Big Three (Novak Djokovic, Rafael Nadal and himself) to keep dominating at the Grand Slams next year, as the next generation of players are now "playing with the big boys, and being really able to challenge and beat us". Medvedev seems to be playing on a different level and I see him being too strong for Stefanos Tsitsipas in this match. "I just gave him enough time to really dictate the play from back of the court and he deserved to win". More to follow... [WATCH LIVE 1].
"I wasn't really thinking that long term that I have to win two sets".
Prior to Friday's match, Fognini said Medvedev was one of the most unsafe players to face.
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Djokovic says that he is fully recovered from a shoulder injury and he did not drop a set in winning the title in Tokyo last week.
"He's got one of the biggest serves of all time, he's one of the tallest guys ever to play tennis".
Federer was left shaking his head in the first set and he suffered a rare inelegant moment in the 12th game, slipping on his own sweat - "a bit embarrassing", said the former number one.
In the decider, the Greek broke at the third breakpoint in the fourth game to go up by 3-1, before finally sealed the victory 6-3.
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Tsitsipas, runner-up at the China Open last week, continued to put the Serbian under pressure, though, and got the elusive break to level the match as he continued to unleash victor after winner.
Matteo Berrettini made it two Italians into the quarterfinals with a 7-6 (5) 6-4 victory over Roberto Bautista Agut.
It means that Nadal, back in Europe with a sore wrist and due to be married, is mathematically assured of regaining the top position on November 4, regardless of what happens in the Paris Masters that takes place the previous week. "He served for the set at 6-5".
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But his unrest was largely down to the brilliance of Zverev, who defiantly overcame the setback of missing out on five match-point openings in the second set. "I won five games in a row, and that was the key, obviously having a break each set, and then I kind of held my serve. He was so much better than at the U.S. Open", Federer said of his Belgian opponent who he beat in straight sets in last month's Grand Slam.