Looking distressed and bursting into tears, she decried a system that was fed by "the fantasy of tabloids".
Knox and her ex-boyfriend, Raffaele Sollecito, spent four years in prison after initially being convicted of the murder. Her throat had been cut and she had been sexually assaulted.
Knox, who had always declared her innocence, spoke about the moment she was found guilty for the first time and sentenced to 26 years in jail in 2009.
Cricket World Cup wettest in history
Rain has washed out two World Cup matches so far: Pakistan vs Sri Lanka in Bristol and South Africa vs West Indies in Southampton. In the World Cup 2019, a steady game of rain could affect the team India match which registered two victories in the tournament.
Before leaving her home in Seattle for Italy, she posted a photo on Instagram of her clinging to a mountain edge alongside the caption: "3 Days till I return to Italy for the first time since leaving prison".
A retrial in 2014 reinstated Ms Knox and Mr Sollecito's convictions but Italy's top appeals court finally overturned their convictions in 2015.
Rudy Guede, originally from the Ivory Coast, is serving a 16-year sentence for the crime, but judges in the previous trials ruled he did not act alone. Knox had told investigators that she "covered her ears as he [Lumumba] killed".
The conference has been organised by a group of Modena lawyers and the Italy Innocence Project, which focuses "on the issues related to wrongful convictions and miscarriages of justice". "I know many people think I am wicked", said the American.
Despite being cleared of Meredith's murder by an Italian supreme court back in 2015, Knox told a conference in Modena on Saturday she "still fears more charges".
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Freeland said any legislation should preserve Hong Kong's autonomy, judicial independence and rule of law. More than 1,000 people joined a peaceful "mothers' protest " on Friday evening in a city centre garden.
Knox will take part in a debate on the subject of "trial by media" on Saturday. "The investigation was contaminated and the jury corrupted, it was impossible for me to have a fair trial".
"The fact I continue to be held responsible for the Kerchers' pain shows how powerful false narratives can be and how they can undermine justice, especially when reinforced and amplified by the media", said Knox.
Both Ms Knox and Ms Kercher were young students and the alleged sexual nature of the murder played a key part in fuelling media interest. She also wrote: "If nothing else, I can remain sure that the last time I saw her, when I touched her frozen cold body and lay a kiss on her cheek for the last time, the determination to live, the struggle and the fight that she put up on the evening of 1 November despite being outnumbered, was clear to see".
Since her release, Knox has written a book about her experience - "Waiting To Be Heard: A Memoir" - been the subject of a Netflix documentary, and become a public advocate for inmates who have been wrongfully imprisoned.
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China called for all sides to "resolve the conflict through dialogue", while the European Union called for "maximum restraint". Pompeo said USA policy was to make economic and diplomatic efforts to bring Iran back to negotiations on a broader deal.