"It's going to be a tough match, he's the greatest ever clay court player", said Nishikori.
After playing so confidently in her 6-4, 6-2 victory that ended Osaka's 16-match Grand Slam winning streak, Siniakova allowed Keys to dictate things to the tune of a 26-10 advantage in winners.
Djokovic saved that, though, as Struff netted, and he booked a quarter-final spot on his first match point.
Men's fourth round: No. 1 Novak Djokovic beat Jan-Lennard Struff 6-3, 6-2, 6-2; No. 4 Dominic Thiem beat No. 14 Gael Monfils 6-4, 6-4, 6-2; No. 5 Alexander Zverev beat No. 9 Fabio Fognini 3-6, 6-2, 6-2, 7-6 (5); No. 7 Kei Nishikori beat Benoit Paire 6-2, 6-7 (8), 6-2, 6-7 (8), 7-5; No. 10 Karen Khachanov beat No. 8 Juan Martin del Potro 7-5, 6-3, 3-6, 6-3.
Nishikori was thrashed 6-1, 6-1, 6-3 by Nadal at Roland Garros, the eighth time in his career that he has fallen in the quarter-finals of a major.
"He nearly had it today", said Nishikori who had led two sets to one when the last-16 tie was suspended on Sunday.
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"It's going to a great match and a tough battle against Novak, the world number one, it's going to be interesting", said Zverev who is 2-2 against Djokovic in his career.
Wawrinka avoided starting with a drop of serve when Federer missed with a forehand and the 20-time major victor, who came out on top in a sensational 26-shot rally in game five, had seen four opportunities go begging by the time the match reached 4-3 and remained on serve.
It marked the third time in four matches that Zverev has dropped at least a set, having already survived two five-setters.
The clay courts of Roland Garros host the second Grand Slam of the season. Not only hasn't he lost a set - he's only twice ceded as many as four games in a set.
"When it goes in, it's called a hot-shot", said the 25-year-old.
Thiem will face 10th-seeded Karen Khachanov a 7-5, 6-3, 3-6, 6-3 victor over No. 8 Juan Martin del Potro.
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In the women's draw, Johanna Konta reached the semifinals for the first time after beating last year's runner-up Sloane Stephens 6-1, 6-4.
"I can't describe how excited I am", Anisimova said of her upcoming clash with Halep. David Goffin was his first genuine threat, and the Belgian became the only opponent to take a set off him so far.
In the women's event, the players who stunned top seed Naomi Osaka and 23-time major victor Serena Williams got a taste of their own medicine. But he also has not faced a seeded player yet.
"I started playing much better from 5-3, playing more aggressive, using my forehand", Nishikori said.
Barty beat Sofia Kenin, who stunned Williams in the third round, 6-3, 3-6, 6-0, on Court Philippe Chatrier.
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Après un match nul 1-1 à l'aller au Maroc, les Tunisiens avaient ouvert le score en fin de première période. Frustré par cette décision, les joueurs du Wydad ont alors demandé à l'arbitre de recourir à la VAR.