The President appears especially angered after Conway tweeted out several psychiatric disorders he suggests are appropriately associated with Trump's behaviors.
"Congratulations! You just guaranteed that millions of more people are going to learn about narcissistic personality disorder and malignant narcissism!" Somebody needs to tell Mr. Melania Trump to #BeBest.
Conway said the president was a "counterpuncher" and had not fired back at her husband - who has targeted Trump on Twitter in the past - "out of respect for [her]".
She then turned her criticism to the news outlet.
"I have four kids and I was getting them out of the house this morning to talk to the President about substance so I may not be up to speed on all of them (his tweets)", she said Monday.
De tristes confidences sur la santé de Chirac
Un jour, Bernadette est entrée dans un nuage de fumée, elle a vu toutes nos victuailles. Il serait dans son fauteuil, les yeux dans le vague , parfois fermés.
Trump had also complained to Conway about his former Attorney General Jeff Sessions, ranting about how "smart" it was for Conway not to have taken a job at the Justice Department.
He later doubled-down while addressing reporters, adding: "I don't know him".
On Wednesday, after Trump's latest tweet, George Conway, posted a link to the diagnostic criteria for narcissistic personality order, and wrote in response to Trump's latest missive: "You. Are".
"He's just trying to get publicity for himself", Trump said when asked about Conway's op-ed.
"I have reluctantly concluded, however, that for me and my family, this is not the right time for me to leave the private sector and take on a new role in the federal government", Conway wrote. "Kellyanne is a wonderful woman, and I call him Mr. Kellyanne", Trump added. Conway goaded when the president lashed out.
Trump rips McCain yet again: 'I was never a fan'
President Donald Trump revealed Tuesday that he is still not happy with late Republican Arizona Sen. On Sunday, Trump tweeted about McCain and the Russian Federation dossier again.
Conway retweeted several of his old tweets attacking Trump, and ones that were retweeted by Duty to Warn, an "association of mental health professionals warning Trump is psychologicallly [sic] unfit".
"George was so excited, literally crying with joy in his MAGA hat ― black, not red ― with his MAGA hat on election night", she told CNN.
The White House did not immediately respond to a request for comment. "The mendacity, the incompetence, it's just maddening to watch".
Trump also sought Wednesday to justify his Twitter bullying habits, slamming the media in the process. "That's basically it. Frankly, it's so I don't end up screaming at her about it". "Most of the unsolicited emails I've gotten have been positive", he said.
Half of Americans see a Trump victim of witch hunt
Trump jumped on the survey's finding that half of Americans agree with his claim that the Mueller probe is a "witch hunt". This is nearly a solid four points higher than the 46.8 percent that said "no".