The north Londoners hold a commanding 3-0 lead from the first leg and will be expected to progress to the quarter-finals in the competition which represents their last hope of silverware this term.
However, Pochettino, 47, is far from happy with having a day less to prepare for the last 16 tie at Dortmund's Signal Iduna Park.
Spurs almost suffered a third successive defeat on Saturday in the north London derby, but Lloris saved Pierre-Emerick Aubameyang's late penalty to maintain his side's four-point cushion ahead of Arsenal.
"We need to play like always we play, trying to win, that is important", he said.
"It's not fair for the players, for the team to compete with a massive disadvantage".
Red Wings legend Lindsay dead at 93
Pearson Award, given annually to the most outstanding player as voted on by the players, to the Ted Lindsay Award. He also started the Ted Lindsay Foundation , which has raised millions of dollars for autism research.
They played 24 hours before them for the first leg and then played on Friday night compared to Spurs' Saturday lunchtime kick-off ahead of the return leg in Dortmund.
"We played Saturday and the only way we can prepare is talking and not talking too much because the players need to rest, need to recover after a very tough game", Pochettino told his pre-match press conference.
"I am not going to blame someone, maybe we need to blame ourselves because we struggled to deal with this type of thing".
"The thing for us now is, kind of like this [last] week, when the pressure's on and we need to step up, we need to find a way to get it done".
A 1-1 draw against arch-rivals Arsenal at Wembley on Saturday left Spurs 10 points behind Premier League leaders Manchester City in the table, with nine matches remaining this season.
Ce que dit la tribune d'Emmanuel Macron — "Renaissance européenne"
Après sa lettre aux Français , le président de la République a écrit une longue lettre aux citoyens européens. Il fixe deux ambitions: "0 carbone en 2050, division par deux des pesticides en 2025".
"I think we need help from the FA, we need help from the Premier League, I don't know because I am not involved in the decisions", the Argentinean said.
The Argentinian repeatedly said Spurs must "forget" their heavy first-leg win at Wembley and finish the job by seeing off a Dortmund team who have one win in seven games.
Son Heung-min, Jan Vertonghen, and Fernando Llorente all got on the score sheet that night to give Spurs a huge advantage for their trip to Dortmund.
"We need to be more sensitive to the clubs who play in Europe to provide better condition to have the same possibility to arrive to the games".
They will try to become the first UCL team to qualify after losing the first leg on the road by a 3-0 scoreline.
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Mahmudullah battled on and was the second to last wicket to fall, caught by Boult off Southee. Mahmudullah and Sarkar weren't the only batsmen to give New Zealand a fight.
"There is no, "Oh, we're Tottenham, we haven't won the league since God knows when".