In the absence of Mako Vunipola in the front row there will be more responsibility on Sinckler's shoulders and Gatland believes the loose head's injury has left England with a huge void.
Wales have gone for the attacking instincts of Gareth Anscombe over the composed kicking of Dan Biggar to form an experienced halfback combination with Gareth Davies.
"Jack will start and Joe will come onto the bench".
England coach Eddie Jones has made it clear he wants his players to keep their cool at the Principality Stadium, where victory for either of the last two unbeaten sides in the Championship could go a long way to deciding the destiny of the title.
Usually when a team comes to town to take on Wales they arrive several days early in order to get settled before they take on Gatland's men. Travelling to Dublin as underdogs, England physically dominated Grand Slam champions Ireland as they won 32-20.
While it's hard to define a decade as a moment, Wales' incredible record against England throughout the 1970s was certainly a special period for Wales supporters. "We're intense rivals and there is the historical context to it", Jones said.
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The Times Ireland reports that United Kingdom police think a present or former airport employee was behind the incident. After Thursday's incident, Ireland's main opposition party Fianna Fail called for more government action.
"There is no doubt he's a very good player, but there is a challenge with his temperament", Gatland said.
"I want my players to bring that physicality and be emotional, but I don't want them going over the top, losing their edge or getting involved in foul play".
'There is a danger we can get overly emotive and swept away and be exhausted coming into the game tomorrow, so there is that element of feet on the ground and job of work to prepare ourselves for tomorrow. Their victory in Rome was their second on the continent in a week after the 24-19 win over France in Paris on the opening weekend.
"Just speculation", Gatland said.
"We have been on the road for the first two weeks, and we are looking forward to being back at home and to build on those first two wins and to build on our performance".
'They will try to take us on at set-pieces, use big runners and look to play a territory game and kick a lot.
" "Macron dénonce une " résurgence " inédite depuis 1945 — Antisémitisme en France
La méthode privilégiée est de " renforcer la pression sur les opérateurs " et de les responsabiliser juridiquement. A commencer par trois organisations d'extrême droite: le Bastion social, Blood and Honour Hexagone et Combat 18.
That 26-19 success again proved the starting point for a Grand Slam, as Wales made it two in four years - with another to follow in 2012. He'll be marked by George North, who is bigger but not faster. Jonathan Davies, 12. Hadleigh Parkes, 11.
Mercurial full-back JPR Williams would join the fray, as would irrepressible No.8 Mervyn Davies and playmaker Phil Bennett, in a team that would only lose seven times between 1969 and 1979. Justin Tipuric, 6. Josh Navidi, 5. Cory Hill, 3. Tomas Francis, 2. Adam Beard, 20. Aaron Wainwright, 21.
England Starting XV: 15.
Coming through midfield, Williams stripped the ball from the grasp of Courtney Lawes, kicked ahead and regathered to touch the ball down, in a game that also saw Sam Warburton's magnificent ankle-high chopper on Manu Tuilagi and Leigh Halfpenny's full-blooded tackle on David Strettle right at the death. Jonny May, 10. Owen Farrell (captain), 9.
France - 15 Thomas Ramos, 14 Damian Penaud, 13 Mathieu Bastareaud, 12 Gaël Fickou, 11 Yoann Huget, 10 Romain Ntamack, 9 Antoine Dupont, 8 Louis Picamoles, 7 Arthur Iturria, 6 Wenceslas Lauret, 5 Félix Lambey, 4 Sébastien Vahaamahina, 3 Demba Bamba, 2 Guilhem Guirado (c), 1 Jefferson Poirot.
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This behavior was inadvertently reinforced by YouTube, since its algorithm would then suggest similar videos to the user. Some have criticised him for going public with his claims that paedophiles were using the site's comments section.