Guzman is believed to have led the cartel for decades, and faced a total of 17 charges, including including operating a continuing criminal enterprise conspiring to murder rivals and money laundering.
He could face life behind bars in a maximum security USA prison.
Guzman's wife, Emma Coronel Aispuro, leaves Brooklyn federal court on January 17 after attending the trial.
Even when Guzman was recaptured in 2016 before his extradition to the United States, he was plotting another escape, prosecutor Andrea Goldbarg said in closing arguments.
Jurors convicted Guzman on all 10 counts in an worldwide drug distribution trial that lasted more than three months.
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The 61-year-old was found guilty today by a NY court of operating the huge criminal enterprise and is expected to be given life in prison.
Unlike other people in a similar position, Guzman would not plead guilty and went for a public trial after being extradited to the US.
Jeffrey Lichtman, centre, a defence attorney for Joaquin "El Chapo" Guzman, speaks to reporters at federal court in NY.
"Senor judge, me and my attorneys have spoken about this", Guzman stated. When the jury was discharged, he leaned back in his chair to catch the eye of his wife, Emma Coronel Aispuro, who gave him a subtle thumbs-up. Guzman smiled and waved, and she touched her hand to her chest.
Jurors in a federal court in Brooklyn have delivered a guilty verdict on all 10 charges in a high point of the 11-week long trial, with several of the carrying a life sentence.
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Guzman's lawyers say he was set up as a "fall guy" by Ismael "El Mayo" Zambada, a powerful drug lord from Sinaloa who remains at large.
U.S. District Judge Brian Cogan lauded the jury's meticulous attention to detail and the "remarkable" approach it took toward deliberations.
President Andres Manuel Lopez Obrador was elected past year after promising a change to the deadly military-led war against drug gangs, suggesting a negotiated peace and amnesty for non-violent drug dealers, traffickers and farmers. President Andres Manuel Lopez Obrador was elected a year ago after promising a change, suggesting a negotiated peace and amnesty for non-violent drug dealers, traffickers and farmers.
One of the trial's most memorable pieces of evidence came from El Chapo's mistress Lucero Guadalupe Sanchez Lopez, who testified she was in bed in a safe house with an on-the-run Guzman in 2014 when Mexican marines started breaking down his door.
The 61-year-old was a key player in the Mexican drug cartel landscape.
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