It remains a mystery whether Neymar, the side's talisman, will be available for the French champions.
The second leg will take place March 6 at the Parc des Princes.
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The issue with his right foot, similar to one which kept him out for three months last season, is nearly certain to see the 26-year-old miss February 12's trip to Old Trafford and the return leg in Paris on March 6.
And hopes are now nearly non-existent that he will be able to play against United in the return leg in France either.
But the report added that 26-year-old forward could also miss the second leg tie in Paris against Manchester United.
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Neymar, who fractured a metatarsal on the same foot in February, has scored 20 times and registered 10 assists in 23 appearances in all competitions for his French club this season.
Last year, Neymar also had similar injury which ended his season with Paris-Saint-Germain, although he fought back to play for his country at the 2018 World Cup in Russian Federation.
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A PSG statement confirmed that he has suffered a recurrence of the metatarsal injury that threatened his World Cup hopes previous year.