United meanwhile got their second away draw in a row, although they did not struggle to sweep Arsenal aside this weekend, blitzing through the Gunners to a comfortable 3-0 victory on Friday night.
Having left North London with a tactically flawless win over Arsenal, in the Fourth Round on Friday night, Ole Gunnar Solskjaer will take his side back to the capital for an arguably bigger tie in the last 16 after the twelve time winners were drawn against Chelsea this evening.
De Gea not satisfied with Man Utd winning streak
That result made it eight wins out of eight matches since caretaker manager Ole Gunnar Solskjaer was appointed in December. Speaking to Manchester United's website , Herrera said: "We shouldn't go insane with the [Premier League] table".
Chelsea beat United 1-0 in the final at Wembley previous year, when Eden Hazard's first-half penalty was enough to down the 12-times winners, who were then managed by Jose Mourinho. Middlesbrough or Newport will host Manchester City while League One Doncaster will welcome Crystal Palace to the Keepmoat Stadium.
And there's also a London derby in the last 16, as AFC Wimbledon's reward for their fourth round win over West Ham United is another home tie, this time against Millwall.
FA Cup draw - When will the fifth round fixtures take place?
Light snow still possible, cold air expected midweek
The air temperature should remain in the 20s but windchills in Boston and points west will make it feel like it's in the teens. Thursday and Friday will be brutally cold with lows in the single digits and wind chills around -15 degrees.
Barnet play Brentford tonight in the last of the fourth round matches.
Manchester United, Chelsea and Manchester City will be joined in the hat by League Two side Newport County and non-league Barnet.
All games are scheduled to take place between the 15th and 18th of February.
Guardiola unconcerned by schedule's impact on Premier League title race
Same against Burnley , imagine what Newcastle will do in the game and focus on what we have to do. You will be retired and after that take one year for holidays.