Williams will play the victor of the match between her older sister Venus and top seed Simona Halep for a place in the quarter-finals.
Halep offered up the first real test Williams has faced at this year's Australian Open, where she is bidding for an eighth trophy, pushing her throughout a back-and-forth matchup that was a fascinating mix of power, court coverage and shotmaking. It propelled her to stardom, but she has been far from convincing at her first major since. "I thought she did really awesome", Williams said of the youngster.
Williams grabbed a pair of service breaks and a 4-0 lead after less than 15 minutes.
In almost three hours, No.6 seed Elina Svitolina advanced to the second week of the Australian Open.
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Despite a literal slip, she smiled and said she was okay, Osaka did not crumble like the opening set, sending this match into a decider. "I didn't know what to do at a certain point but I just stuck in there".
Though she's yet to capture a Grand Slam title, Keys has recently been remarkably consistent at the year's biggest tournaments.
She'll next play sixth-seeded Elina Svitolina, who fended off five break points in a game in the third set that went to deuce 11 times, contained 28 points, and was pivotal in a momentum-swinging 6-2, 1-6, 6-1 win over 2017 U.S. Open finalist Madison Keys.
Serena Williams comes through Simona Halep battle to reach last eight
However, Serena got the better of her counterpart Halep 6-1, 4-6, 6-4 to reach the quarter-finals of the tournament. The 37-year-old American dismantled Halep's game to race through the opening set in 20 minutes.
"I was happy to handle that pressure at 1-1 in the third set".
"I tried doing things that are not necessarily my game. then after a while I started thinking "I'm in a Grand Slam".
Hsieh eventually stopped the rot, but only after dropping the first two games of the final set.
While Osaka is a frequent visitor to Japan, she hasn't spent much time in Haiti. Serena got a crucial break in the seventh game in the third set to cement her position in the next stage. Then the Japanese failed to serve out the set, and that was the moment that something broke in her performance.
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Osaka fell heavily late in the set but shook off any discomfort and proceeded to open the final set with a break after smashing a sizzling cross-court backhand. The world number four had to be sure she would not have a let down after having a chance to go 3-0 up. Hsieh finally began to tire and the younger player was in control as she closed out the match.