Those two, and seventh seed Dominic Thiem, are in the same quarter as Alexander Zverev, who could meet Djokovic in the semifinals but must first plot his way past Aljaz Bedene in the opening round.
A highlight first-round clash will see Australia's unseeded Nick Kyrgios up against Canada's big-serving 16th seed Milos Raonic, with the victor facing either Stan Wawrinka or Ernests Gulbis.
Five-time Melbourne Park runner-up Andy Murray, on the comeback trail from injury, faces 22nd-seeded Spaniard Roberto Bautista Agut in the first round.
Banque Mondiale : le président Jim Yong Kim démissionne
Kristalina Georgieva , l'actuelle directrice générale de la Banque mondiale, assumera sa succession à titre intérimaire à partir du 1 février.
He said: "Ninety-nine is already an incredible number".
"I always have tried to remind myself that this is a dream", Federer said of his longevity at the draw ceremony held at Margaret Court Arena, where he discovered the world number 99 would be his opening opponent. "Reaching 100 would be truly very special for me".
"The door is open, if you look at the rankings. You have (Denis) Shapavalov in the 20s, (Borna) Coric is in the low teens, so you have a lot of players positioned to make a big breakthrough".
Second-seeded Angelique Keber is in the same half as Wozniacki and has 2017 U.S. Open champion Sloane Stephens in her quarter.
Fantastic Four DLC content coming to Marvel’s Spider-Man
Spider-Man's final piece of DLC in The City That Never Sleeps trilogy, Silver Lining, released just before the new year. The best bet is maybe a costume change or perhaps the addition of the Baxter Building to the NY skyline.
Marin Cilic, who lost last year's final to Federer, will begin his 2019 campaign against home hope Bernard Tomic. Among those looking to halt Serena's charge: world number one Simona Halep, defending champion Caroline Wozniacki and US Open victor Naomi Osaka.
Defending champion Caroline Wozniacki takes on Belgian Alison van Uytvanck in round one and could potentially meet 30th seed Maria Sharapova in the third round.
Murray, who has scheduled a news conference on Friday at Melbourne Park, admitted to still feeling pain in his hip before Brisbane. "I've had a great off-season and I feel very well prepared". "I'm just enjoying every minute of it".
The draw for the first Grand Slam of the season was made on Thursday and the top seeds could face some early tests of their credentials when play gets underway in Melbourne on Monday.
Suspicious packages found at multiple foreign consulates in Melbourne, Canberra
Australian police are investigating suspicious packages found at foreign consulates and embassies in Melbourne and Canberra . Australian Federal Police are now examining the packages, which were delivered to consulates on St Kilda Rd and in the CBD.