Wesley Hoedt turned Sane's sixth-minute cross into his own goal before Sterling laid on the first of his assists, crossing for Sergio Aguero to claim the 150th Premier League goal of his career - putting the Argentine equal-eighth with Michael Owen in the division's all-time goalscoring list.
It is important to be there than below but the distance of two or three points is nothing.
City were on top right from kick-off with Sterling and Aguero proving hard to handle for the Southampton defence; and just five minutes in, had taken the lead.
"The key is to keep our concentration for as long as we can, and they are human, so they will make mistakes too".
And the lead atop the table is just two points heading into a week with a Champions League visit from Shakhtar Donetsk and City's home Manchester Derby.
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UN Chief "offered assistance in facilitating a dialogue with all the parties to resolve the situation", his office added. However, there has been no statement from President Sirisena or Prime Minister Rajapakse since then.
"In the first 10 to 15 minutes of any game you have to be stronger than we were in that period".
"It was an incredible performance but still with the young guys like him and Leroy [Sane] I would feel he can improve". It is a tough league but it is important we are stable.
Sterling, 23, has now scored six goals and provided another five assists in the Premier League this season.
"We were brilliant at times".
"He was looking, who is the guy I am going to pass the ball to?"
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Carla, jusqu'à aujourd'hui, c'est ma fille. "Elle est connue pour ça." a expliqué David Ginola. Je trouve ça inadmissible par rapport à elle", a-t-il déploré auprès de Thierry Ardisson .
Just before half time Raheem Sterling registered his account in the match with a fine finish as City took a 4-1 lead into the break.
"I was lucky at the end with the goal", said Sane.
"He is a top player but still is so young to consider it is the world's best players", Guardiola told a news conference.
"Any other work you've prepared in the week and the game plan that you want to implement against a very good Manchester City side goes out of the window when you concede so early", said Hughes.
"If he is stable and he focuses on what he has to do to become a better and better player, if he has this on his mind, he can reach whatever he wants".
"He is more mature now than he was when we first met at the club". But it's much easier to improve after winning than to improve after losing.
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Et d'asséner: " Jamais je n'aurais pu cacher un tel crime , c'est horrible. J'ai tenté de sortir une fois dans la cour mais j'ai reçu des projectiles.