It was thanks to his header that Uruguay beat Italy 1-0 in their decisive group game in Brazil to reach the last 16 of the last World Cup and even though they fell to Colombia in the next round, the memory of the goal lives on.
One more and he will equal 1950 World Cup-winner Oscar Miguez's Uruguayan record of eight goals at the tournament.
The unquestionable driving force and inspiration for Fernando Santos' men, Ronaldo flew out of the blocks in this tournament but missed a penalty and might have been sent off in a tempestuous encounter with Iran.
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These two countries with a combined population of 13.5 million have always been overachievers on the worldwide scene - the last decade under Tabarez has seen two-time former winners Uruguay reach one World Cup semi-final and win one Copa America, while Portugal triumphed at Euro 2016.
Since Uruguay and Portugal have not faced each other since a friendly match in 1972, Cristiano Ronaldo hasn't had the chance to take on Suarez and Cavani together, but he has done it separately and scored more than both. Not just (Diego) Godin.
Godin is an expert at keeping clean sheets, as the leader of an Atletico defence that is the most formidable in the European club game - they kept 34 in all competitions last season - and of a Uruguay side that has not conceded a goal in 2018 in six games.
One player who could significantly help Uruguay in trying to contain Ronaldo is defender Jose Maria Gimenez, who missed the group stage finale with a thigh injury. Nearly irrespective of who those wins came against, Uruguay will be on a high as one of only three teams to triumph in all their group games in Russia-Croatia and Belgium are the other two.
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Uruguay will be looking to win their opening four games at a World Cup tournament for only the second time after 1930 when they won the first ever World Cup. Meanwhile, three of Portugal's last four goals have come from outside the box.
This is Fernando Santos' fourth major tournament in a row as manager.
The 2018 FIFA World Cup kicked off on June 14 and will continue until July 15, with the matches being played in 11 cities across Russian Federation. They are very good at the back, have a couple of excellent forwards and they go from there.
Who wins Portugal-Uruguay? And where does all the value lie?
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