Sanford becomes just the second sitting member of Congress to lose in a primary this year.
The race is perhaps the most closely watched matchup in Tuesday's slate of primaries, which also include Virginia selecting a Republican to take on Democratic Sen. Nevada, North Dakota, Maine and Virginia also chose candidates for the midterm election on November 6, when Democrats hope to capture a majority of the U.S. Congress.
His biggest challenger, state Rep. Katie Arrington, has characterized Sanford as a disloyal Never-Trumper.
Four other states held primaries. On Capitol Hill, Sen. Bob Corker (R-Tenn.) - who is not running for reelection - taunted his Senate colleagues for their reluctance to "poke the bear" and take more authority over tariffs.
"A lot of people have come up to me in the course of this campaign and asked me, 'Are you for or against Trump?' And I'd say, 'I'm neither for nor against Trump". 'But it comes to, you can not walk away from it if you're really listening to the people I spend so much time with here at home'. So far, CNN has been unable to project a victor in the Maine House District or either the Democrat or Republican primary for Maine governor.
California to vote on proposal to split state into three parts
The three-states campaign, dubbed "Cal-3", submitted more than 600,000 signatures. "Californians deserve a better future". If the measure is approved by voters, it would have to be ratified by Congress, which analysts say is unlikely.
'Great night for Republicans!' tweeted Trump. In North Dakota, GOP Representative Kevin Cramer was declared the party's primary victor, setting him up to run against Democratic Senator Heidi Heitkamp.
Likewise in Nevada, the race is set between incumbent Sen. Democrats in Nevada chose Representative Jacky Rosen, a first-term lawmaker and member of the centrist Problem Solvers Caucus, to challenge GOP Senator Dean Heller.
On the Democratic side, one-term Rep. Jacky Rosen was projected as the victor over five long-shot candidates. Trump won the district in 2016 by a margin of 53% to 40%.
And in suburban Richmond's Seventh District, former Central Intelligence Agency officer Abigail Spanberger was declared the victor for the Democratic nomination, setting the stage for a fall campaign against GOP Representative David Brat.
Democrats notched another win in state legislative special elections on Tuesday, the party's 43rd red-to-blue flip since President Donald Trump stepped into the White House a year ago. Horsford won his primary Tuesday and Hardy was leading in early returns. In the 4th District, vacated by retiring Rep. Ruben Kihuen, two former congressmen - Democrat Steven Horsford and Republican Cresent Hardy - are the favorites.
National and state Republicans are hopeful that Freitas will win, but don't see any of the candidates as likely to pose a real threat to Kaine. Clark County Commissioners Steve Sisolak and Clark County Commissioner Christina Giunchigliani are the front-runners among Democrats. This means that on the ballot, voters rank the candidates from their favorite to least favorite.
Kim Jong Un sent a letter to Trump. It's huge
Trump has refused to publicly acknowledge whether he's spoken directly with Kim Jong Un ahead of the talks. Since taking power in 2011, Kim has not publicly met with another head of state in North Korea .
Democrats need to gain 23 seats to win the majority in the House.
Businessman Shawn Moody led the Republicans' four-way race for governor.
ME voters are deciding how they'd prefer to veer in their search for the successor to term-limited, conservative Republican Gov. Paul LePage.
Golden was leading late Tuesday. In both cases, the races for what once were relatively secure Republican seats now are rated as toss-ups by the non-partisan Cook Political Report.
He's been known as South Carolina's political comeback kid, but his luck just ran out.
La Belgique de Thomas Meunier domine le Costa Rica (4-1)
La Belgique démarre son Mondial lundi prochain contre le Panama, avant d'affronter la Tunisie le 23 juin et l'Angleterre le 28. Eden Hazard est sorti en boîtant mais n'a rien de grave. "J'ai apprécié sa prestation", dit Martinez.