California Highway Patrol officials responded to the crash, involving two FedEx semi-trucks and a auto, shortly before 1:30 a.m. near the Lake Avenue exit.
Train service was disrupted and three lanes of the westbound 210 Freeway at Lake Avenue were closed for a little over eight hours.
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CHP Officer Ryan Bejar said a second Fedex tractor trailer later collided with the sedan.
The second truck's cab and one trailer were left on their side in freeway lanes, while a second trailer ended up on the Gold Line's tracks. Then a second big rig, a FedEx truck, hit the vehicle and overturned.
Metro spokesman Rick Jager said the truck ended up on two sets of tracks, blocking traffic near the Lake Station.
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Free shuttle buses began operation at 4 a.m. and will continue to replace Gold Line service between Memorial Park and Allen Station until the issue is resolved.
The driver of the Volkswagen fled on foot and has not been found, the CHP reported. He didn't know where they were heading.
"A short while later, a second truck. was traveling westbound on I- 210, near Lake Avenue, and collided with the disabled sedan, " a CHP statement said. He said two lanes reopened at 2:18 a.m.
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Brandt said all westbound lanes were open around 10:35 a.m.