Spurs were left chasing shadows as the Blues knocked the ball around purposefully and with speed and after just four minutes, the visitors' superiority was so almost rewarded as Leroy Sane's sumptuous volley smacked against the inside of the post from Raheem Sterling's cross.
Things went from bad to worse for Spurs and their captain as Lloris' reckless lunge on Sterling - which appeared outside of the area - handed City a penalty which Gundogan coolly slotted home.
Tottenham Hotspur: Lloris (C), Trippier, Sanchez, Vertonghen, Davies, Dier, Dembele, Lamela, Eriksen, Dele and Kane. Vincent Kompany, Ilkay Gundogan and Fabian Delph returned as Manchester City made three changes.
Spurs reduced the deficit with four minutes remaining in the half as Aymeric Laporte's attempted clearance hit Christian Eriksen and sailed into the back of the net.
Unusually sluggish, Tottenham didn't test City and, with a swagger back in their stride, Guardiola's men took the lead in the 22nd minute.
'Escalation' fears grow as United States ponders Syria strike
The government, however, said evacuations from Douma were continuing, and no Syrian government forces had entered the town. He said there was a heightened "danger of escalation" because of the Russian military presence in Syria .
But it quickly became clear that run of three successive defeats wasn't weighing on City.
Suddenly Spurs were on the front foot and it looked like City might blow a two-goal lead for the second time in a week, after Manchester United's 3-2 comeback win in the derby.
They still sit 13 points clear of United atop the Premier League table with six matches left to play as they head into this fixture with Spurs.
AFC Bournemouth has an unenviable week of action coming up in the Premier League.
It's fair to say the Liverpool man did not take kindly to the news that the Premier League had eventually added the goal to Kane's tally.
Jaguar Land Rover to cut 1000 jobs at Solihull
JLR employs some 40,000 people in total making it the UK's biggest vehicle manufacturer in terms of both output and heads. Earlier this year, it said it would cut production amid uncertainty over Brexit and changes to taxes on diesel cars.
The Citizens have conceded eight goals in their last three games, which they all lost.
City were dumped out of the Champions League by Liverpool and missed the chance to seal top spot against rivals Manchester United over the last week but Pep Guardiola's men put on a sizzling display at Wembley to get back to winning ways.
Last-chance saloon for the Baggies?
The pre-match build-up starts at 7pm on Sky Sports Premier League (7.30pm on Sky Sports Main Event), before kick-off at 7.45pm.
Otherwise a City victory in their next game against Swansea on 22 April will be enough.
Blizzard conditions lead to I-80 pileup in western Nebraska
More than 100 motorists reportedly got help from Nebraska authorities after getting stuck in blizzard conditions on Friday. In total, more than 100 motorists were rescued, Cody Thomas, public relations director with the Nebraska State Patrol said.