AC Milan won the Champions League in 2007, beating Liverpool, while Arsenal appeared in the final a year before that, going down to Barcelona.
Milan spurned two good openings in the first 10 minutes, with Giacomo Bonaventura just missing a cross at the left-hand post and Patrick Cutrone firing into the side-netting after escaping Shkodran Mustafi.
Arsenal, meanwhile, have lost four games in a row for the first time in over a decade.
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However, Mkhitaryan reminded everyone exactly what he is capable of with some attractive control before rocketing a fine effort past the Milan keeper.
Arsenal hopes to overcome their setback in the Premier League by achieving a victory over Milan.
"We need to defend well first, because when teams lack a little bit of confidence you need reassurance".
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The Armenia global has showed few flashes of brilliance since arriving from Manchester United in January, but showed his quality in a competition where he has thrived since moving to England.
Arsenal signed Manchester United midfielder Hernikh Mkhitaryan in a swap deal in the January transfer window.
AC MILAN have no fresh injury or suspension concerns ahead of the game.
Mesut Ozil has become an Arsenal centurion, with the World Cup victor having now been involved in 100 Gunners goals.
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That assist saw him reach a notable landmark, with a hand having been played in 100 goals.
There is no denying the scale or significance of the job that Arsenal face against AC Milan tonight.
Le 8 mars une fête surtout commerciale
Elle peut exposer des affiches sur les arbres ou sur les panneaux afin d'exprimer leurs souhaits pour cette journée, où encore des citations...